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Title Abstract Background Hypothesis Specific Aims Methods - Design Methods - Data Collected Methods - Statistical Analysis Patient Characteristics Duration of Intubation Duration of ICU Stay Multiple Intubations Summary Future

Weaning protocols have shortened the duration of mechanical ventilation for many patients However, there are several impediments which delay extubation such as Persistence of the underlying disorder Hypoxia Respiratory muscle weakness Inability to protect the airway Respiratory secretions may impede weaning through several such mechanisms.  They may Lead to plugging Interfere with gas exchange Promote atelectasis Many diseases in the ICU (e.g., pneumonia, COPD, aspiration) are associated with excess secretions Many patients have a depressed mental status and lung disease which may interfere with their ability to handle secretions